Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives

K Shinozaki; H Sato; T Iwakuma; R Sato; T Kurimoto; K Yoshida

doi:10.1016/s0960-894x(99)00014-1

Synthesis and thromboxane A2 antagonistic activity activity of indane derivatives

Bioorg Med Chem Lett. 1999 Feb 8;9(3):401-6. doi: 10.1016/s0960-894x(99)00014-1.

Authors

K Shinozaki¹, H Sato, T Iwakuma, R Sato, T Kurimoto, K Yoshida

Affiliation

¹ Central Research Laboratories, Zeria Pharmaceutical Co., Ltd., Ohsatogun, Saitama, Japan.

PMID: 10091692
DOI: 10.1016/s0960-894x(99)00014-1

Abstract

A new series of indane derivatives were prepared and evaluated for their thromboxane A2 (TXA2, 1) antagonistic activity. Among these compounds, 24a (Z-335) was found to be a potent TXA2 antagonist in oral administration.

MeSH terms

Animals
Aorta / drug effects
Aorta / physiology
Indans / chemical synthesis*
Indans / chemistry
Indans / pharmacology*
Muscle Contraction / drug effects
Platelet Aggregation Inhibitors / chemical synthesis
Platelet Aggregation Inhibitors / chemistry
Platelet Aggregation Inhibitors / pharmacology
Rabbits
Rats
Thromboxane A2 / antagonists & inhibitors*

Substances

Indans
Platelet Aggregation Inhibitors
Thromboxane A2